PgdA
PgdA, also known as phosphogluconate dehydrogenase, is an enzyme found in many organisms, playing a crucial role in metabolic pathways. It is a key component of the pentose phosphate pathway (PPP), a vital cellular process that generates NADPH and produces precursor molecules for nucleotide and amino acid biosynthesis. Specifically, PgdA catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose-5-phosphate, releasing carbon dioxide and NADPH in the process.
In bacteria, PgdA is essential for the efficient operation of the PPP, which is particularly important under
In eukaryotes, the enzyme is also present and contributes to the PPP. The regulation of PgdA activity