Pericytoplasm

Pericytoplasm is a term used in microbiology to describe the cellular compartment found in some bacteria that lies between the cytoplasmic membrane and the outer membrane. This space is analogous to the periplasmic space found in Gram-negative bacteria. However, the term pericytoplasm is specifically used for bacteria that possess a S-layer, a proteinaceous or glycoproteinaceous layer, as their outermost cell covering, situated external to the outer membrane. The pericytoplasm contains a variety of proteins, including enzymes involved in nutrient acquisition, detoxification, and cell wall metabolism. These proteins are often released into the external environment or can play roles in interactions with the host cell. The composition and function of the pericytoplasm can vary significantly between different bacterial species. Understanding the pericytoplasm is important for comprehending bacterial physiology, pathogenesis, and for the development of antimicrobial strategies. It represents a distinct compartment with specialized functions that contribute to the overall survival and adaptation of these bacteria.