Pd4

Pd4 refers to the gene responsible for encoding the protein palladin. Palladin is a protein that plays a crucial role in the actin cytoskeleton, which is a dynamic network of protein filaments essential for cell structure, movement, and division. The gene is located on human chromosome 14.

The palladin protein is found in various cell types, particularly those involved in cell migration and tissue development, such as fibroblasts and muscle cells. It is known to interact with other proteins involved in actin regulation, influencing the organization and dynamics of actin filaments. This interaction is vital for processes like cell adhesion, cell spreading, and cell motility.

Mutations in the Pd4 gene have been linked to certain human diseases, although research is ongoing to fully understand these associations. Aberrant palladin function or expression has been observed in some cancers, suggesting a potential role in tumor progression and metastasis. Further investigation into the Pd4 gene and its protein product continues to shed light on its involvement in normal cellular functions and its contribution to disease states.