PTCH12

PTCH12, also known as Patched 12, is a gene that encodes a protein also called Patched 12. This protein is a member of the Patched family of transmembrane proteins, which are known to act as receptors for hedgehog signaling pathway ligands. The hedgehog signaling pathway plays a crucial role in embryonic development, cell growth, and tissue repair. PTCH12, specifically, is thought to function as a tumor suppressor. Its precise mechanisms of action are still being investigated, but it is believed to regulate cell proliferation and differentiation. Mutations in the PTCH12 gene have been associated with an increased risk of certain cancers. Research into PTCH12 is ongoing, focusing on understanding its role in normal development and disease, and exploring its potential as a therapeutic target.