PRKN
PRKN, also known as parkin, is a protein encoded by the PRKN gene in humans. This gene is located on chromosome 6. Parkin plays a crucial role in cellular processes, particularly in the ubiquitin-proteasome system, which is responsible for degrading damaged or misfolded proteins. It functions as an E3 ubiquitin ligase, a key component that tags proteins for destruction by the proteasome.
Mutations in the PRKN gene are a significant cause of early-onset Parkinson's disease. Parkinson's disease is