PRFN1

PRFN1, also known as Peripherin-1, is a protein encoded by the PRFN1 gene in humans. This gene is located on chromosome 14 and plays a role in the nervous system. Peripherin-1 is a type III intermediate filament protein, and it is primarily expressed in neurons. Intermediate filaments are a crucial component of the cytoskeleton, providing structural support and maintaining cell shape. In neurons, peripherin-1 contributes to the stability of the axonal cytoskeleton, which is essential for nerve cell function and maintenance.

Research suggests that PRFN1 is involved in neuronal development and repair processes. It has been observed to accumulate in damaged neurons, indicating a potential role in neuroprotection or regeneration. Mutations in the PRFN1 gene have been linked to certain neurological disorders, although the precise mechanisms are still under investigation. Further studies are ongoing to fully elucidate the functions of PRFN1 and its implications in health and disease. Its expression pattern and structural role make it a significant protein for understanding neuronal physiology and pathology.