PLCG
PLCG refers to Phospholipase C gamma, a family of enzymes that play a crucial role in cellular signaling pathways. These enzymes are involved in the hydrolysis of phosphoinositides, a class of lipids found in cell membranes. Specifically, PLCG enzymes cleave phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG).
IP3 acts by binding to receptors on the endoplasmic reticulum, triggering the release of calcium ions into
There are several isoforms of PLCG, including PLCG1 and PLCG2, which exhibit distinct tissue distributions and