PKG2

PKG2 is a protein-coding gene found in humans. It is also known by the symbol ZDHHC8. The protein encoded by this gene is a zinc finger DHHC-type palmitoyltransferase. Palmitoylation is a post-translational modification process where a palmitoyl group is attached to a protein, typically on cysteine residues. This modification can influence protein localization, stability, and function.

The ZDHHC8 protein is thought to be involved in the palmitoylation of various substrate proteins, though the specific targets and their functional consequences are still under investigation. Research suggests that ZDHHC8 may play a role in cellular processes such as cell signaling, protein trafficking, and neurodevelopment. Studies have linked mutations or dysregulation of PKG2 to certain neurological disorders, indicating its importance in the proper functioning of the nervous system. Further research is ongoing to fully elucidate the precise biological functions and clinical implications of PKG2.