PGGT2
PGGT2, also known as Piggyting2, is a gene that encodes a protein involved in glycosylation. Glycosylation is a process where carbohydrate molecules called glycans are attached to proteins and lipids. This process is crucial for a wide range of biological functions, including cell recognition, signaling, and immune responses. The PGGT2 protein specifically functions as a protein O-GlcNAcase. It catalyzes the removal of N-acetylglucosamine (O-GlcNAc) residues from serine and threonine hydroxyl groups of proteins. This O-GlcNAcylation modification is dynamic and sensitive to nutrient availability, playing a role in cellular metabolism and signaling pathways.
Mutations or dysregulation of PGGT2 have been implicated in various human diseases. Research suggests a link