PDR16

PDR16 is a yeast gene that encodes a protein involved in DNA repair. It is a homolog of the mammalian gene XPC, which plays a crucial role in nucleotide excision repair (NER). NER is a major DNA repair pathway that removes bulky DNA lesions, such as those caused by UV radiation, from the genome.

In yeast, PDR16 is thought to function in a pathway that senses DNA damage and initiates the NER process. The protein has been shown to interact with other proteins involved in DNA repair, suggesting its involvement in a complex molecular machinery. Studies have indicated that mutations in PDR16 can lead to increased sensitivity to DNA damaging agents, highlighting its importance for genomic stability.

The exact molecular mechanism by which PDR16 recognizes DNA damage is still under investigation. However, research suggests that it may bind to damaged DNA directly or indirectly through interactions with other damage recognition factors. Understanding the function of PDR16 is important for comprehending the intricate mechanisms of DNA repair in eukaryotes and may have implications for understanding human diseases associated with DNA repair defects. Further research is ongoing to fully elucidate the role of PDR16 in DNA repair and its potential involvement in other cellular processes.