PCSiin
PCsiin, or Protein-Cell Signaling Interaction Network, is a computational framework for modeling intracellular signaling networks. It combines curated protein interaction data with quantitative cellular measurements to simulate how signals travel through pathways and influence cellular states.
Developed by a consortium of computational biology researchers in the 2010s, PCsiin is designed to be modular
Architecture of PCsiin centers on a graph-based core where nodes represent signaling entities such as proteins,
Inputs to PCsiin include omics data such as proteomics, phosphoproteomics, and transcriptomics; public pathway databases; user-provided
Applications of PCsiin span modeling disease-specific signaling alterations, identifying potential drug targets, evaluating combination therapies, and
See also: systems biology, network biology, signaling pathway, pathway analysis.