PCDHG

PCDHG is a gene that encodes a protein belonging to the protocadherin superfamily. Protocadherins are cell adhesion molecules that play crucial roles in the development and function of the nervous system. The PCDHG gene, like other protocadherin genes, is characterized by a large number of isoforms that are generated through alternative splicing. These isoforms can differ in their extracellular domains, which are involved in cell-cell recognition, and their intracellular domains, which mediate signaling pathways.

The expression of PCDHG is primarily observed in the brain, particularly in neurons. Its precise function is still under investigation, but it is thought to contribute to the establishment of neuronal circuitry and the maintenance of neuronal integrity. The diversity of PCDHG isoforms suggests a role in fine-tuning cell-cell interactions within complex neural networks. Research into PCDHG has explored its potential involvement in neurodevelopmental disorders and neurological diseases. Understanding the molecular mechanisms by which PCDHG operates could offer insights into the intricate processes of brain development and function. The study of this gene and its protein products is an active area of research in molecular biology and neuroscience.