PARP5

PARP5, also known as ADP-ribosylhydrolase 3 (ARH3), is a protein-coding gene. It is part of the poly(ADP-ribose) glycohydrolase (PARG) family of enzymes, which are involved in the processing of poly(ADP-ribose) (PAR) chains. PARylation is a post-translational modification that plays critical roles in various cellular processes, including DNA repair, gene expression, and cell death. PARP5 specifically functions to cleave PAR chains, thereby reversing the PARylation process.

The gene encoding PARP5 is located on chromosome 19 in humans. Its expression is found in a wide range of tissues, suggesting a broad physiological importance. Research has indicated that PARP5 interacts with other proteins involved in DNA damage response pathways. While the precise functions of PARP5 are still under investigation, its role in regulating PARylation levels is crucial for maintaining cellular homeostasis. Dysregulation of PARP5 activity or expression has been implicated in certain disease states, although its specific contributions to these conditions are not yet fully understood. Further research is ongoing to elucidate the full spectrum of PARP5's biological functions and its potential as a therapeutic target.