P2Xsubenheter
P2X receptors are a subclass of ionotropic purinoceptors, which are ligand-gated ion channels activated by extracellular nucleotides, primarily adenosine triphosphate (ATP). These receptors are named for their sensitivity to purines, particularly ATP, and are categorized into P2X and P2Y subtypes based on their structural and functional differences. The P2X receptor family consists of seven distinct subunits, labeled P2X1 through P2X7, each encoded by separate genes.
P2X subunits assemble as trimers to form functional ion channels, allowing the influx of cations (primarily
P2X receptors are widely expressed across various tissues, including the central and peripheral nervous systems, immune
The study of P2X subunits involves molecular biology, electrophysiology, and pharmacology to elucidate their structure-function relationships