P11Db

P11Db is a public database that catalogs proteins and sequences containing the P11 domain, a compact structural motif found in a diverse set of organisms. The resource aims to support functional annotation, evolutionary analysis, and structure prediction for P11-domain containing proteins. Each entry in P11Db includes the amino acid sequence, organism, length, domain architecture, predicted function, and links to external resources such as UniProt, PDB, Pfam, and InterPro. In addition, curated notes describe experimental evidence, when available, and predicted cellular localization.

The database aggregates data from multiple sources, including curated protein catalogs and genome annotations, and applies automated quality checks followed by manual review. Entries are annotated with confidence scores and cross-referenced to related domains and families. P11Db also offers classification schemes that group proteins by organismal lineage, domain order, and predicted function, enabling researchers to explore evolutionary relationships and functional diversity of the P11 domain.

Access is provided through a web interface, a downloadable sequence set, and an API for programmatic queries. Users can search by sequence similarity, identifier, organism, or functional keywords, and can submit new sequences for inclusion through an established curation workflow. The project began in the early 2010s and is maintained by a collaboration of molecular biology and bioinformatics groups. P11Db has been cited in studies of domain evolution and protein interaction networks and serves as a reference point for researchers investigating P11-domain proteins.