ORC2

ORC2, also known as Origin Recognition Complex subunit 2, is a protein that plays a crucial role in DNA replication. It is a component of the Origin Recognition Complex (ORC), a multi-subunit protein complex essential for initiating DNA replication in eukaryotic cells. The ORC binds to specific DNA sequences called origins of replication, serving as a landing pad for other proteins involved in the replication process.

ORC2 specifically interacts with other ORC subunits and contributes to the overall stability and function of the complex. Its precise role in the binding to DNA and the subsequent recruitment of replication factors is an area of ongoing research. Dysregulation or mutations in ORC2 have been implicated in various cellular processes and diseases, including cancer, highlighting its importance in maintaining genomic stability. Understanding the structure and function of ORC2 is vital for comprehending the fundamental mechanisms of DNA replication and its implications in health and disease.