OMPS
Outer membrane proteins (OMPs) are a broad class of proteins located in the outer membrane of Gram-negative bacteria, and they include homologous proteins found in the outer membranes of mitochondria and chloroplasts. In bacteria, most OMPs are beta-barrel proteins that function as channels, receptors, transporters, or adhesion factors. They are typically synthesized with an N-terminal signal peptide that directs them through the Sec pathway into the periplasm, where chaperones guide them to the outer membrane and the beta-barrel assembly machinery (Bam) inserts them into the membrane. Lipoprotein-anchored OMPs use the Lol system to reach the outer membrane.
Most OMPs share a common structural theme: a beta-barrel spanning the outer membrane, formed by 8 to
Functions of OMPs include nutrient uptake, waste efflux, and maintenance of membrane integrity, as well as roles
In eukaryotes, mitochondrial and chloroplast outer membranes contain homologous beta-barrel proteins derived from bacterial ancestors, but