Nonprotonated

Nonprotonated refers to a molecule or atom that has not gained a proton (H+). In chemistry, protonation is a common process where a species accepts a proton, typically from an acid. This addition of a proton often changes the charge and chemical properties of the species.

For example, a water molecule (H2O) can be protonated to form a hydronium ion (H3O+). Therefore, H2O is considered nonprotonated in this context. Similarly, an amine group (NR2) can be protonated to form an ammonium ion (HNR2+). When the amine group exists as NR2, it is nonprotonated.

The term nonprotonated is often used in contrast to protonated. It signifies the state of a substance before or without the addition of a proton. This distinction is important in understanding acid-base chemistry, reaction mechanisms, and the behavior of molecules in different environments, particularly in aqueous solutions where proton transfer is prevalent. The degree of protonation or lack thereof can significantly influence a molecule's solubility, reactivity, and biological activity.