Neurotensins

Neurotensins are a group of peptides that act as neurotransmitters or neuromodulators in the nervous system. They play a role in various physiological processes, including pain perception, feeding behavior, and emotional regulation. The term "neurotensin" specifically refers to a well-characterized peptide found in both the central and peripheral nervous systems. It is synthesized from a precursor protein and is released from neurons in response to specific stimuli.

The neurotensin receptor is a G protein-coupled receptor that mediates the effects of neurotensin. Binding of neurotensin to its receptor triggers intracellular signaling cascades that ultimately alter neuronal activity. In the brain, neurotensin has been implicated in modulating dopamine neurotransmission, which is relevant to conditions such as schizophrenia and Parkinson's disease. In the periphery, neurotensin influences gastrointestinal motility and blood pressure. Research into neurotensins continues to explore their diverse functions and potential therapeutic applications.