NUF1

Nuf1, also known as NUF1 or nuclear fragile site protein 1, is a protein encoded by the NUF1 gene. It is a conserved protein found across various species, suggesting a fundamental biological role. The NUF1 gene is located on human chromosome 17. Nuf1 is primarily found in the nucleus, though it can also be detected in the cytoplasm.

Research suggests that Nuf1 plays a role in DNA repair pathways. It has been implicated in the response to DNA double-strand breaks and in maintaining genomic stability. Studies have indicated that Nuf1 interacts with other proteins involved in DNA repair, such as those related to the non-homologous end joining (NHEJ) pathway. Furthermore, Nuf1 has been associated with the regulation of cell cycle progression, particularly at checkpoints that monitor DNA integrity. Alterations in NUF1 expression or mutations have been linked to certain types of cancer, highlighting its potential involvement in tumorigenesis. The precise molecular mechanisms by which Nuf1 functions are still under investigation, but its involvement in DNA repair and genomic stability makes it a protein of interest in cancer biology and cell cycle regulation.