NSP4B

NSP4B is a non-structural protein found in some strains of the porcine epidemic diarrhea virus (PEDV). Porcine epidemic diarrhea virus is a highly contagious enteric coronavirus that causes severe diarrhea and vomiting in pigs, leading to significant economic losses in the swine industry. NSP4B is one of several non-structural proteins encoded by the PEDV genome, meaning it is not a part of the infectious viral particle itself but plays a crucial role in viral replication within the host cell.

The precise functions of NSP4B are still being investigated, but it is believed to be involved in the formation of the double-membrane vesicles (DMVs) that serve as the replication sites for coronaviruses. These DMVs are essential for protecting viral RNA from host immune defenses and for facilitating the replication process. NSP4B may interact with other viral proteins, such as NSP4A, and host cell factors to assemble and organize these replication complexes. Understanding the role of NSP4B could provide insights into the mechanisms of PEDV replication and potentially lead to the development of new antiviral strategies. Research into NSP4B is ongoing to fully elucidate its contribution to the viral life cycle and pathogenesis.