NAE1UBA3

NAE1UBA3, also known as NAE1 UBA3, is a protein-coding gene. This gene encodes a protein that is part of the NEDD8 activating enzyme complex. The NEDD8 activating enzyme is crucial for the conjugation of NEDD8, a ubiquitin-like protein, to target proteins. This process, known as neddylation, plays a significant role in various cellular functions, including protein folding, cell cycle progression, and signal transduction.

Mutations or dysregulation in NAE1UBA3 can lead to various cellular abnormalities. Research into NAE1UBA3 and its associated pathways is ongoing, with potential implications for understanding and treating diseases where neddylation is implicated, such as certain types of cancer and developmental disorders. The protein's interaction partners and precise regulatory mechanisms are areas of active investigation within molecular biology and biochemistry. Understanding the function of NAE1UBA3 contributes to a broader comprehension of ubiquitin-like protein conjugation systems and their cellular impact.