NADPHoxidázishiánya
NADPH oxidase deficiency refers to a group of inherited disorders that impair the function of the NADPH oxidase enzyme complex. This complex is crucial for the immune system, particularly in phagocytic cells like neutrophils and macrophages. Its primary role is to generate reactive oxygen species (ROS), which are toxic molecules used by these cells to kill ingested bacteria and fungi.
When NADPH oxidase is deficient, these phagocytic cells are unable to produce sufficient ROS. This significantly
The severity of CGD depends on the specific subunit of the NADPH oxidase complex that is affected