NADPHmolekyylien

NADPHmolekyylien, or Nicotinamide Adenine Dinucleotide Phosphate in its reduced form, is a crucial coenzyme found in all living organisms. It plays a vital role in numerous metabolic processes, primarily as a reducing agent in anabolic pathways. NADPH is generated through various pathways, including the pentose phosphate pathway and the citric acid cycle. Its primary function is to provide the high-energy electrons required for biosynthetic reactions, such as fatty acid synthesis, cholesterol synthesis, and nucleotide synthesis. These anabolic processes are essential for cell growth, repair, and maintenance.

Beyond its role in biosynthesis, NADPH is also critical for protecting cells from oxidative stress. It serves as a substrate for enzymes like glutathione reductase, which regenerates reduced glutathione. Reduced glutathione is a key antioxidant that neutralizes reactive oxygen species, thereby preventing cellular damage. Furthermore, NADPH is involved in the detoxification of various harmful compounds, including drugs and xenobiotics, by providing reducing equivalents for enzymes in the cytochrome P450 system. The balance of NADPH levels within a cell is therefore tightly regulated to ensure optimal cellular function and survival.