N6MeK

N6MeK is a short form that typically refers to the compound N6-methyllysine. This is a post-translational modification of the amino acid lysine, where a methyl group is attached to the epsilon-amino group of the lysine side chain. This modification is found in various proteins and plays a role in a range of cellular processes.

The methylation of lysine residues can occur on proteins involved in DNA binding, chromatin structure, and transcriptional regulation. For example, N6MeK has been identified on histone proteins, where its presence can influence the interaction of histones with DNA and other proteins, thereby affecting gene expression. The specific consequences of N6MeK on protein function are often context-dependent and can vary based on the protein and the specific lysine residue that is methylated.

Enzymes known as lysine methyltransferases are responsible for catalyzing the addition of methyl groups to lysine residues, forming N6MeK. Conversely, enzymes called lysine demethylases can remove these methyl groups. This reversible nature of lysine methylation allows for dynamic regulation of protein function and cellular signaling pathways. Research into N6MeK continues to uncover its diverse roles in biological systems, including development, disease, and cellular homeostasis.