Monoamiinioksidaasi

Monoaminiinooksidaasi is an enzyme that catalyzes the oxidation of monoamines, which are organic compounds containing a single amino group. This enzyme plays a crucial role in the metabolism of various neurotransmitters, including dopamine, norepinephrine, and serotonin. Monoaminiinooksidaasi is primarily found in the mitochondria of neurons and is responsible for the degradation of these neurotransmitters by converting them into aldehydes, which are then further metabolized into carboxylic acids. This process helps regulate the levels of neurotransmitters in the brain, influencing mood, cognition, and behavior. Monoaminiinooksidaasi is a target for several antidepressant and antipsychotic medications, as inhibiting this enzyme can increase the availability of neurotransmitters in the brain. The enzyme is encoded by the MAO gene family, which includes two main isoforms: MAO-A and MAO-B. These isoforms have distinct substrate specificities and are involved in different physiological processes. Monoaminiinooksidaasi is an essential enzyme in the central nervous system, and its dysregulation has been linked to various neurological and psychiatric disorders.