Mel1a

Mel1a is a gene that encodes a protein involved in circadian rhythm regulation. The protein produced by the Mel1a gene is a type of G protein-coupled receptor. It is primarily expressed in the pineal gland and retina. This receptor plays a crucial role in mediating the effects of melatonin, a hormone that signals darkness and influences sleep-wake cycles. Melatonin binds to the Mel1a receptor, triggering a cascade of intracellular signals that ultimately affect the body's internal clock. Variations or mutations in the Mel1a gene have been associated with certain sleep disorders and differences in seasonal affective disorder susceptibility. Research continues to explore the precise mechanisms by which Mel1a influences circadian timing and its broader implications for health.