Malonaattiyksiköt
Malonaattiyksiköt, known in English as malonate units, are a concept used in organic chemistry to describe the building blocks of certain molecules, particularly in the context of biosynthesis and synthetic pathways. The malonate unit is derived from malonic acid, a dicarboxylic acid with the formula CH2(COOH)2. Specifically, it refers to the fragment -CH2-CO- when incorporated into a larger molecule. This structural motif is crucial because the methylene group (-CH2-) situated between two carbonyl groups (-CO-) is highly acidic.
The enhanced acidity of the methylene protons in malonate derivatives is due to the electron-withdrawing nature
In biological systems, the malonate unit is famously involved in fatty acid biosynthesis. Acetyl-CoA and malonyl-CoA