MDM4MDMX
MDM4MDMX refers to a class of molecules designed to interact with both MDM2 and MDM4 proteins. MDM2 and MDM4 are E3 ubiquitin ligases that play crucial roles in regulating the tumor suppressor protein p53. Under normal conditions, MDM2 and MDM4 target p53 for degradation, thereby preventing excessive cell proliferation. However, in many cancers, these proteins are overexpressed or mutated, leading to the inactivation of p53 and uncontrolled tumor growth.
MDM4MDMX compounds are developed as potential cancer therapeutics. The goal of these molecules is to simultaneously
The development of dual MDM2/MDM4 inhibitors represents an advancement over single-target inhibitors, as both MDM2 and