MCM27Helikasekomplex
The MCM2-7 helicase complex, also called the MCM2-7 hexamer, is a conserved eukaryotic protein assembly essential for DNA replication. It comprises six related AAA+ ATPases—MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7—that come together to form a hexameric ring capable of encircling DNA and providing the helicase activity required at replication forks.
In late M or early G1 phase, replication origins are licensed by the origin recognition complex (ORC)
Entry into S phase triggers activation of the complex, primarily through phosphorylation by CDKs and DDK (Dbf4-dependent
Regulation of MCM2-7 loading and activation is crucial for genome stability. Inappropriate licensing or activation can
Evolutionarily, MCM genes are highly conserved in eukaryotes, with archaeal MCMs sharing structural and functional similarities.