LCGC

LCGC is an acronym used in analytical chemistry and related disciplines. It most commonly stands for Liquid Chromatography–Gas Chromatography, a way to refer to the use of both chromatographic techniques in research and industry. Liquid chromatography (LC) and gas chromatography (GC) separate compounds based on interactions with a stationary phase and a mobile phase, but they are suited to different classes of analytes: LC handles nonvolatile or thermally labile substances; GC requires volatility and thermal stability. In some workflows, laboratories employ LC and GC sequentially or in tandem, sometimes with interface technologies that allow transfer of analytes between platforms or with hyphenated detectors such as LC-MS or GC-MS.

In addition, LCGC is the name of a trade publication and online resource devoted to chromatographic science, covering instrumentation, method development, applications, and news in LC and GC. The publication serves practitioners in academia and industry seeking practical guidance, technical reviews, and case studies.

Applications span environmental analysis, pharmaceutical quality control, food safety, clinical diagnostics, and forensic science. Advances in detector technologies, column chemistries, and data analysis have expanded the capabilities of LC and GC, enabling more sensitive, selective, and high-throughput analyses.

Common topics include method development strategies, sample preparation, column selection, instrument maintenance, and regulatory considerations. The term LCGC may thus refer either to the analytical concept of combining LC and GC or to the industry publication that documents developments in these fields.