Kremen1

Kremen1 is a gene that encodes a protein involved in cell proliferation and differentiation. The protein produced by the Kremen1 gene is known to be a type II transmembrane protein. It plays a role in the Wnt signaling pathway, a crucial signaling cascade involved in embryonic development and the regulation of cell growth and fate. Specifically, Kremen1 has been identified as an antagonist of the Wnt/beta-catenin signaling pathway. It functions by binding to LRP5/6 co-receptors, thereby inhibiting the downstream signaling events that are triggered by Wnt ligands. This inhibitory action suggests Kremen1's importance in maintaining a balance within the Wnt pathway, which is critical for preventing uncontrolled cell growth that can lead to developmental abnormalities or cancer. Research has indicated that dysregulation of Kremen1 expression can be associated with certain types of cancer, highlighting its potential as a therapeutic target or biomarker.