Kollateralbildung

Kollateralbildung refers to the biological process of forming new blood vessels from pre-existing ones. This intricate process is crucial for tissue survival and repair, particularly in situations where blood supply is compromised. When oxygen or nutrient delivery to a tissue is insufficient, cells within that tissue release signaling molecules, collectively known as angiogenic factors. These factors stimulate the proliferation and migration of endothelial cells, the primary building blocks of blood vessels.

The formation of new vessels involves several key stages. Initially, a parent vessel may sprout a new tube, or a new vessel can form by the fusion of previously separated endothelial cells. This process can lead to the development of a network of smaller vessels that bypass blocked or damaged larger vessels, thereby restoring blood flow. This collateral circulation is vital for recovery from events like heart attacks or strokes, where immediate restoration of blood supply is critical. The extent and effectiveness of kollateralbildung can vary significantly between individuals and depending on the specific tissue involved. Factors such as genetics, age, and the presence of certain diseases can influence the capacity for collateral vessel formation. Research continues to explore ways to enhance or induce kollateralbildung therapeutically to treat a range of ischemic conditions.