Kolesevelánokat

Kolesevelánokat refers to a class of anion-exchange resins used primarily in medicine for the treatment of hyperphosphatemia. These compounds are non-absorbable polymers that bind to phosphate ions in the gastrointestinal tract, preventing their absorption into the bloodstream. By reducing phosphate absorption, kolesevelánokat help to lower elevated phosphate levels in patients with chronic kidney disease who are on dialysis.

The active ingredient in medications containing kolesevelánokat is typically colesevelam hydrochloride. It is administered orally, usually with meals. The resin works by exchanging its chloride ions for phosphate ions in the gut lumen. This complex is then excreted in the feces. In addition to phosphate, kolesevelánokat can also bind to other anions, such as bile acids, which can lead to a reduction in LDL cholesterol levels. This dual action makes it a valuable therapeutic option for some patients.

Common side effects associated with kolesevelánokat include gastrointestinal disturbances such as constipation, nausea, and abdominal pain. It can also interfere with the absorption of certain vitamins and medications. Therefore, it is important for patients to consult with their healthcare provider to determine if kolesevelánokat is appropriate for their condition and to manage potential interactions.