Kir34

Kir34 is a hypothetical member of the inward-rectifier potassium channel (Kir) family that appears in theoretical discussions about ion-channel diversity. The designation Kir34 is provisional and has not been linked to a verified gene or protein in public databases. In these discussions, Kir34 is used to explore how sequence variation within the Kir family could influence channel architecture and regulation.

Structure and predicted features: Kir34 is described as sharing the canonical Kir topology, with two transmembrane helices (M1 and M2) flanking a pore-forming loop and cytoplasmic N- and C-termini. The predicted molecular mass is around 34 kilodaltons, consistent with the name. Like other Kir channels, Kir34 would be expected to form tetrameric assemblies in the membrane and to allow potassium conductance that is inwardly rectifying under physiological voltages.

Function and regulation: In silico models propose that Kir34 would contribute to setting resting membrane potential and to potassium buffering in neural tissue. Its activity could be modulated by intracellular magnesium and polyamines, as well as by pH and ATP levels, with interaction partners potentially altering trafficking or gating.

Research status: Kir34 remains a theoretical construct used to illustrate channel-family diversity and to guide computational studies. It has not been observed in experimental systems, and no experimental protocols are described for its isolation or characterization.

See also: Inward-rectifier potassium channels, Kir family, potassium homeostasis, KCNJ genes.