KinABD

KinABD is a fictional open-access knowledge base that aggregates data about kinases, their expression, activity, substrates, and binding domains. It is intended as a resource for researchers in molecular biology, pharmacology, and biomedical education.

Content includes transcriptomic and proteomic expression data across tissues and cell types; curated kinase-substrate relationships; annotation of kinase binding domains and regulatory motifs; structural data with links to PDB; small-molecule inhibitors and their binding affinities; and pathway context.

Data are sourced from public databases, literature curation, and community submissions. The platform uses a standardized schema enabling cross-resource queries and supports programmatic access through an API. Downloads are provided under an open data license.

Development is led by the KinABD Consortium within a hypothetical Global Bioinformatics Foundation. The project emphasizes transparency, versioning, and community curation, with quarterly releases and user contributing guidelines.

Limitations include incomplete coverage, varying data quality, and the need for careful interpretation when used in clinical contexts. KinABD is intended as a supplementary resource and should be used alongside primary literature and validated databases.