Ketolytic
Ketolytic is an adjective relating to ketolysis, the metabolic process by which ketone bodies are converted into usable energy in the form of acetyl-CoA. In mammalian metabolism, ketolysis happens primarily in extrahepatic tissues, because the liver itself lacks the key enzymes to fully utilize ketone bodies for energy.
During periods of fasting, prolonged carbohydrate restriction, or intense exercise, the liver produces ketone bodies—acetoacetate, 3-hydroxybutyrate
The main steps of ketolysis in mitochondria involve several enzymes. First, acetoacetate is activated to acetoacetyl-CoA
Physiologically, ketolysis provides a crucial energy supply when glucose is limited. The brain, heart, and skeletal