Kaskaproteiinit

Kaskaproteiinit, also known as casein kinase 1 (CK1) isoforms, are a family of serine/threonine protein kinases involved in a wide array of cellular processes. These enzymes play crucial roles in regulating circadian rhythms, DNA damage response, cell cycle progression, and signal transduction pathways. There are multiple kaskaprotein genes in mammals, leading to a diverse set of kinase isoforms, each with potentially distinct substrates and functions. The activity of kaskaproteins is regulated by phosphorylation, protein-protein interactions, and cellular localization.

Dysregulation of kaskaprotein activity has been implicated in various human diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. For example, certain CK1 isoforms have been found to be overexpressed or mutated in tumors, contributing to uncontrolled cell proliferation. Research into kaskaproteins continues to uncover their complex regulatory networks and therapeutic potential. Their involvement in fundamental cellular processes makes them important targets for drug development aimed at treating a range of pathologies.