KPIt120

KPIt120 is a type of potassium ion channel, specifically a transient outward potassium current (Ito) channel. It is a member of the transient outward potassium channel family, which plays a crucial role in the repolarization phase of the cardiac action potential. The KPIt120 channel is expressed in various tissues, including the heart, brain, and smooth muscle cells. It is activated by depolarization and inactivated by repolarization, contributing to the shaping of the action potential duration and the refractory period of excitable cells. The channel is composed of four subunits, each containing six transmembrane domains. Mutations in the KPIt120 gene have been linked to various cardiac arrhythmias and other neurological disorders. The channel's function can be modulated by various pharmacological agents, making it a target for therapeutic interventions in cardiovascular diseases.