KMT2E1

KMT2E1, also known as MLL5, is a human gene that encodes a protein belonging to the lysine methyltransferase family. These enzymes are involved in the epigenetic regulation of gene expression by catalyzing the methylation of histone proteins. Histone methylation is a crucial post-translational modification that can alter chromatin structure and influence the accessibility of DNA to transcription factors, thereby affecting gene transcription.

The MLL5 protein is characterized by several functional domains, including a SET domain, which is the catalytic core responsible for methyltransferase activity, and a CXXC-type zinc finger motif. This zinc finger domain is thought to play a role in DNA binding and potentially in recruiting the protein to specific genomic loci. MLL5 has been implicated in various cellular processes, including cell proliferation, differentiation, and development. Its dysregulation has been associated with certain types of cancer, though its precise role in tumorigenesis is still an active area of research.

Research into KMT2E1 has focused on understanding its specific targets, the mechanisms by which it regulates gene expression, and its involvement in normal physiological processes and disease states. Further investigation is needed to fully elucidate the complex functions of MLL5 and its potential as a therapeutic target.