KIR2DL23

KIR2DL23 is a gene that encodes a protein belonging to the killer-cell immunoglobulin-like receptor (KIR) family. These receptors are primarily expressed on natural killer (NK) cells and some T cells, playing a crucial role in immune surveillance and regulation. The KIR2DL23 protein is an inhibitory receptor, meaning that when it binds to its ligand, it sends a signal into the NK cell that suppresses its cytotoxic activity. This prevents NK cells from attacking healthy host cells that express the corresponding ligand.

The specific ligand for KIR2DL23 is classical Human Leukocyte Antigen (HLA) class I molecules. However, the precise HLA alleles that bind to KIR2DL23 are not fully characterized and can be complex, often involving specific combinations of HLA-C alleles. Variations in the KIR2DL23 gene and its interactions with HLA molecules can influence an individual's susceptibility to certain infections and autoimmune diseases. Research into KIR2DL23 is ongoing, aiming to understand its precise role in immune responses and its potential therapeutic implications in areas such as transplantation and cancer immunotherapy. The gene is located on chromosome 19q13.4.