KC2H

KC2H, also known as 2-keto-4-hydroxyglutarate, is a metabolic intermediate involved in the tricarboxylic acid (TCA) cycle, a key pathway in cellular energy production. It is derived from the metabolism of certain amino acids and other compounds within the cell.

The compound is formed through the enzymatic action of 2-hydroxyglutarate dehydrogenase, which catalyzes the conversion of 2-hydroxyglutarate (2HG) to 2-ketoglutarate (2KG) and then to KC2H. This process is part of the cellular mechanism to regulate the levels of 2HG, which can accumulate in certain disease states, such as cancer and neurological disorders.

KC2H is notable for its role in the regulation of cellular metabolism and its potential involvement in disease pathways. Elevated levels of 2HG, which can lead to the formation of KC2H, have been observed in various types of cancer, including glioblastoma and paraganglioma. This has sparked interest in the potential use of KC2H and related metabolites as biomarkers for disease diagnosis and prognosis.

Research into KC2H is ongoing, with studies focusing on its biochemical properties, its role in cellular metabolism, and its potential as a therapeutic target. Understanding the functions and regulation of KC2H may provide insights into the development of new treatments for diseases associated with metabolic dysregulation.