JAKkinaser
JAKkinaser is a hypothetical protein used in teaching and theoretical models to illustrate the JAK-STAT signaling pathway. It is described as a member of the Janus kinase (JAK) family of non-receptor protein tyrosine kinases that typically associate with cytokine receptors at the cell membrane and relay signals to the nucleus through phosphorylation of signal transducer and activator of transcription (STAT) proteins.
In these models, JAKkinaser would be cytoplasmic and contain the conserved domains seen in canonical JAKs:
Activation and signaling would proceed when a cytokine binds its receptor and causes receptor dimerization, allowing
Regulation of JAKkinaser in these scenarios includes inhibition by endogenous mechanisms such as SOCS proteins and
Note: There is no gene or protein officially named JAKkinaser in current scientific databases; the term serves