Isoformispesifisyys

Isoform specificity refers to the phenomenon where a protein or enzyme exhibits different functional properties depending on its specific isoform. Isoforms are variants of a protein that arise from alternative splicing, post-translational modifications, or genetic mutations. These variants can have distinct amino acid sequences, which can lead to differences in their structure, stability, localization, and interaction partners. Consequently, isoform specificity allows for the fine-tuning of cellular processes and the regulation of biological functions. For instance, in the case of the enzyme creatine kinase, different isoforms are found in various tissues, each with unique substrate preferences and regulatory properties. Understanding isoform specificity is crucial for comprehending the complexity of protein function and for developing targeted therapies for diseases associated with specific protein isoforms.