Insuliinisignalinemä
Insuliinisignalinemä, also known as insulin signaling pathway, is a fundamental cellular process that regulates glucose metabolism and cellular growth. It is initiated when the hormone insulin binds to its receptor on the surface of target cells, such as muscle, fat, and liver cells. This binding event triggers a cascade of intracellular events.
The insulin receptor, a tyrosine kinase, undergoes autophosphorylation upon insulin binding. This activates downstream signaling molecules,
Akt plays a crucial role in mediating many of insulin's effects. In muscle and fat cells, Akt
Dysregulation of the insulin signaling pathway is implicated in several metabolic diseases, most notably type 2