Immunocheckpoint
Immunocheckpoints are proteins that regulate the immune system's response to infection and cancer. They are found on the surface of immune cells and play a crucial role in maintaining immune tolerance, preventing autoimmunity, and controlling inflammation. Immunocheckpoints are typically inhibitory, meaning they suppress the immune response, but there are also activating checkpoints that enhance immune activity.
The most well-known immunocheckpoints are programmed cell death protein 1 (PD-1) and its ligand PD-L1. PD-1 is
Immunocheckpoint inhibitors are a class of drugs that block these inhibitory signals, reactivating the immune system
Other immunocheckpoints include cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T-cell immunoglobulin mucin-3 (TIM-3), and lymphocyte-activation gene 3