IkkeIgEmedierte

IkkeIgEmedierte refers to a category of hypersensitivity reactions that are not mediated by immunoglobulin E (IgE) antibodies. These reactions are distinct from the classic IgE-mediated allergies, such as those causing hay fever or anaphylaxis, which involve the rapid release of histamine and other mediators from mast cells and basophils upon re-exposure to an allergen.

Instead of IgE, non-IgE mediated hypersensitivity reactions can involve other immune mechanisms. These include T-cell mediated reactions, which are often responsible for delayed hypersensitivity, such as contact dermatitis from poison ivy or nickel. Immune complex-mediated reactions, classified as Type III hypersensitivity, can also fall under this umbrella. These involve the formation of antigen-antibody complexes that deposit in tissues, triggering inflammation and damage, as seen in serum sickness. Cytotoxic hypersensitivity (Type II) can also occur without IgE, involving antibodies that target cell surface antigens, leading to cell destruction.

Conditions that can be non-IgE mediated include certain food intolerances, some types of drug reactions, and inflammatory bowel diseases. Diagnosing these reactions can be more complex than IgE-mediated allergies, often relying on clinical history, elimination diets, and sometimes specific immunological tests that do not involve IgE measurement. Treatment focuses on avoiding the causative agent and managing the inflammatory response.