IgGvälitteinen

IgGvälitteinen is a Swedish term that translates to "IgG-mediated" in English. It refers to a type of immune response where Immunoglobulin G (IgG) antibodies play a central role. IgG is the most abundant type of antibody in blood and extracellular fluid and is crucial for the secondary immune response.

When the body encounters a pathogen or foreign substance for the first time, other types of antibodies, like IgM, are typically produced initially. However, upon subsequent exposures to the same antigen, the immune system rapidly produces a significantly higher concentration of IgG antibodies. This rapid and robust IgG response is a hallmark of immunological memory.

IgG-mediated immunity can function through several mechanisms. IgG antibodies can bind to pathogens, marking them for destruction by other immune cells such as phagocytes. This process is known as opsonization. They can also activate the complement system, a cascade of proteins that can directly lyse pathogens or further enhance inflammation and phagocytosis. Furthermore, IgG can neutralize toxins or block viruses from entering host cells, preventing infection.

In a clinical context, "IgG-mediated" is often used to describe diseases or conditions where IgG antibodies are implicated in the pathology, such as certain autoimmune diseases where IgG antibodies mistakenly target the body's own tissues. It can also refer to the effectiveness of therapies that involve or target IgG.