IgDmediated

IgDmediated refers to biological processes or immune responses that are triggered or influenced by the antibody isotype immunoglobulin D (IgD). IgD is a type of antibody found on the surface of mature B lymphocytes, where it serves as a B cell receptor (BCR). While its exact functions are still being researched, IgD is believed to play a role in B cell activation, maturation, and tolerance.

Upon encountering an antigen, IgD on the surface of a B cell can bind to it. This binding initiates a signaling cascade within the B cell, contributing to its activation. Activated B cells then undergo proliferation and differentiation into antibody-secreting plasma cells and memory B cells. The IgD isotype is particularly abundant on naive B cells, suggesting its involvement in the initial stages of an adaptive immune response.

Furthermore, IgD is thought to be crucial in maintaining B cell homeostasis and preventing autoimmune reactions. It may contribute to the selection of B cells that are not self-reactive, thereby promoting immune tolerance. Disruptions in IgD-mediated signaling can potentially lead to immune dysregulation. Research continues to uncover the multifaceted roles of IgD in the immune system, including its potential involvement in allergy and other immune-related conditions.