IRPIREMechanismen
IRPIREMechanismen refers to the post-transcriptional regulation of cellular iron metabolism by iron regulatory proteins (IRP1 and IRP2) interacting with iron-responsive elements (IREs) in target mRNAs. This regulatory framework coordinates iron uptake, storage, and utilization by controlling the stability and translation of a subset of transcripts, most notably ferritin and the transferrin receptor.
The core mechanism centers on IRPs binding to IREs, which are conserved hairpin structures located in the
Regulation of IRP activity depends on cellular iron status. IRP1 can exist as an iron-sulfur cluster-containing
Physiological significance includes maintenance of systemic and cellular iron homeostasis, with implications for erythropoiesis, immunity, and